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AZD-9291 shows similar potency to early generation tyrosine kinase inhibitor (TKIs) in inhibiting EGFR phosphorylation in EGFR cells harboring sensitising EGFR mutants including PC-9 (ex19del)
InChiKey: BWWVAEOLVKTZFQ-CXUHLZMHSA-N
induces cell cycle arrest and apoptosis and depletes client proteins in human cancer cells (80 nM)
3-[4-(3-methylbut-2-enoxy)phenyl]-4-(2-methylpropyl)furan-2
NSC 266535
Moxifloxacin hydrochloride 60076 AZD-9291 shows similar potency toMoxifloxacin is a fourth generation synthetic fluoroquinolone antibacterial agent. Its antibacterial spectrum includes enteric Gram () rods (Escherichia coli, Proteus species, Klebsiella species), Haemophilus influenzae, atypical bacteria (Mycoplasma, Chlamydia, Legionella), and Streptococcus pneumoniae, and anaerobic bacteria. It differs from earlier antibacterials of the fluoroquinolone class such as levofloxacin and ciprofloxacin in having greater
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