![MG-277 164015 COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCC4C5=CC=CC=C5NC=4[C@@H]3C[C@@H]21](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M25079_1635947755.gif?v=1635947757)
Pay in 4 interest-free payments of $25.00 Learn more
Ships within 48 hours · Estimated delivery Jul 30 - Aug 4
COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCC4C5=CC=CC=C5NC=4[C@@H]3C[C@@H]21
It Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1
Akt in HER2 overexpressing cell lines
Human Endogenous Metabolite
modestly reduces in mean channel open time
MG-277 164015 COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCC4C5=CC=CC=C5NC=4[C@@H]3C[C@@H]21MG 277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1. 3 nM. MG 277 potently inhibits tumor cell growth in a p53 independent manner, with IC50s of 3. 5 nM for RS4; 11 cells and 3. 4 nM for p53 mutant RS4; 11 IRMI 2 cells, respectively. Anticancer activity. Product information CAS Number: 2411085 89 5 Molecular Weight: 774. 71 Formula: C41H42Cl2FN5O5 Chemical Name: (3'R,4'S,5'R)
US$ 2061.37
US$ 19179.51
US$ 11993.75