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USP10 and USP13
a new anti-cancer drug candidate
specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs)
PubMed Central PMCID: PMC3789222
L002 was shown to occupy Ac-CoA binding pocket of p300
KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60166 USP10 and USP13KYA1797K, CAS No. 1956356 56 1, is a highly potent and selective Wnt catenin inhibitor with IC50 ~0. 75 M (TOPflash assay). It binds directly to the regulators of G protein signaling domain of axin, initiating catenin and Ras degradation through enhancement of the catenin destruction complex activating GSK3. KYA1797K can effectively suppress the growth of CRCs harboring APC and KRAS mutations, as shown by various in vitro studies and by in vivo
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