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Auranofin promotes mitochondrial apoptosis by inducing annexin A5 expression and translocation in human prostate cancer cells
ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases
It is also known to inhibit the epithelila-to-mesenchymal transition and suppresses LPS-stimulated production of pro-inflammatory cytokines in macrophages
GSK650394 at concentrations of 10
IC50=190 nM
Allo-aca 3107 Auranofin promotes mitochondrial apoptosis byAllo aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo aca blocks leptin signaling and action in numerous in vitro and in vivo models. Product information Molecular Weight: 1074. 19 Formula: C48H75N13O15 Chemical Name: (6S, 9S, 12S, 15S, 18S, 21S, 24S) 1 amino 6 ((4 (2 amino 2 oxoethyl) 2 oxo 2H chromen 7 yl)carbamoyl) 24 ((2S, 3R) 2 amino 3 hydroxybutanamido) 9 (hydroxymethyl) 1 imino 12 isobutyl 18
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