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CAS Number: 1184991-14-7
061 nM in Mcl-1 HTRF/TR-FRET assay
CAS Number: 5945-86-8
Bendamustine has potent alkylating
InChi: InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H
MIPS-521 Catalog No.:M33388-100 CAS Number: 1184991-14-7MIPS 521 is a positive allosteric modulator of the A1R, exhibits analgesic efficacy in rats in vivo through modulation of the increased levels of endogenous adenosine that occur in the spinal cord of rats with neuropathic pain. We also report the structure of the A1R co bound to adenosine, MIPS521 and a Gi2 heterotrimer, revealing an extrahelical lipid detergent facing allosteric binding pocket that involves transmembrane helixes 1, 6 and 7. Molecular
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