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(-)-BAY-K-8644
Curr Drug Discov Technol
Smiles: COC1=CC(=CC(OC)=C1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)C2=CC3OCOC=3C=C21
CAS Number: 1210344-83-4
5-3(6)1-2-4(7)8/h6
Cladribine - CAS# 4291-63-8 lbutyric acid (4-PBA) (-)-BAY-K-8644Cladribine is a purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and
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