For the longest time (basically until Counterspell was printed in Modern), Thoughtseize, and to a lesser extent Inquisition of Kozilek, were the only major universal disruption spells in Modern
Skithiryx, the Blight Dragon Skithiryx, the Blight Dragon brings flying, infect, and optional haste, so its a terrifying one-shot threat with the right buffs
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They might also run spot removal in the form of [c]Swords to Plowshares[/c], mass removal in the form of [c]Wrath of God[/c], or both
Without those pointers, I'm not sure I'd have been bitten by the MTG bug